Four short links: 23 September 2009

Video Art, Synthetic Biology Futures, Crowdsourced Personality, and an 1890s Startup

by Nat Torkington | @gnat | comments: 1

1. Projections (YouTube) -- the incredible video projection onto an old English manor house by Kiwi Foo Camp alums The Dark Room.
Where Will Synthetic Biology Lead Us? (New Yorker) -- a thoughtful article about the possibilities and cautions of synthetic biology. . “A house pet is a domesticated parasite,” he noted. “ It is evolved to have an interaction with human beings. Same thing with corn”—a crop that didn’t exist until we created it. “Same thing is going to start happening with energy,” he went on. “We are going to start domesticating bacteria to process stuff inside enclosed reactors to produce energy in a far more clean and efficient manner. This is just the beginning stage of being able to program life.”
2. Business Cards and Crowdsourced Personality Assessments -- we scanned images of a person’s business card and asked crowdsourced workers from the Amazon Mechanical Turk channel to write five kind words about the person based on what they saw. I like the idea of being able to crowdsource a quick impartial aesthetic judgement about a design.
3. When Sears Was a Startup (Pete Warden) -- one of the first catalogues from Sears (1897) inspires comparisons to Amazon and other web startups. On a mission with a new business model. They can't stop talking about how they're cutting out the middle men who've been gouging their customers, with pages devoted to messianic rants against the monopolies trying to put them out of business. They contrast their order fulfillment process (dozens of clerks dealing with tens of thousands of orders a day) with the inefficient country stores full of assistants being paid to idly wait for customers, explaining how they can offer such low prices despite the shipping.

ETech Preview: Creating Biological Legos

by James Turner | comments: 22

If you've gotten tired of hacking firewalls or cloud computing, maybe it's time to try your hand with DNA. That's what Reshma Shetty is doing with her Doctorate in Biological Engineering from MIT. Apart from her crowning achievement of getting bacteria to smell like mint and bananas, she's also active in the developing field of synthetic biology and has recently helped found a company called Gingko BioWorks which is developing enabling technologies to allow for rapid prototyping of biological systems. She will be giving a talk entitled Real Hackers Program DNA at O'Reilly's Emerging Technology Conference, March 9-12, in San Jose, California. And she's joining us here today. Thank you for taking the time.

RESHMA SHETTY: No problem. Happy to be here.

JAMES TURNER: So first of all, how do you make bacteria smell nice, and why? I get an image of a commercial, "Mary may have necrotizing fasciitis, but at least her hospital room smells minty fresh."

RS: Well, the original inspiration for the project was the fact that for anybody who works in a lab, who works with E. coli, when you grow cultures of the stuff, it just smells really bad. It smells really stinky, basically. And so our thought was, "Hey, why don't we reengineer the smell of E. coli? It'll make the lab smell minty fresh, and it's also a fun project that gets people, who maybe aren't normally excited about biology, interested in it because it's a very tangible thing. I can smell the change I made to this bacteria."

JT: So what was the actual process involved?

RS: So the process was, you basically take a gene, we took a gene from the petunia plant, which normally provides an odor to the flower, and you place that gene into the E. coli cell. And by supplying the cell with an appropriate precursor, you make this minty smell as a result. So it's fairly straightforward.

JT: Your degree, biological engineering, is a new one to me. How is it different from biochemistry or microbiology or genomics or any of the other traditional biotech degrees?

RS: Well, biology and biochemistry, and so on, are concerned with studying the natural world. So I'm going to go out and figure out how the natural world works. Biological engineering, instead, is really all about saying, "Hey, we have this natural world around us. Biology is, in some sense, a new technology through which we can build new engineered biological systems." Right? So the idea is, what's the difference between physics and electrical engineering? Electrical engineers want to go build. So in biological engineering, we're interested in going and building stuff, too. But using biology, rather than physics, as the underlying science of it.

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